1,2-Dichloro-4-nitrobenzene → 3-Chloro-4-(4-morpholinopiperidin-1-yl)aniline

HRID 1744547Notes

Reaction equation

HRID 1744547 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-])=O)[CH:5]=[CH:6][C:7]=1Cl.[O:12]1[CH2:17][CH2:16][N:15]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH2:14][CH2:13]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[N:21]1[CH2:22][CH2:23][CH:18]([N:15]2[CH2:16][CH2:17][O:12][CH2:13][CH2:14]2)[CH2:19][CH2:20]1)[NH2:9]

Participants

3

Reactant 2

HCID 74431,2-Dichloro-4-nitrobenzeneHCID 7957244-Morpholinopiperidine

Product 1

HCID 222281773-Chloro-4-(4-morpholinopiperidin-1-yl)aniline

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthesis Example 40 using 3,4-dichloronitrobenzene and 4-morpholinopiperidine, the title compound was obtained, melting point: 220–223° C.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-92d173a67e424c8c9ef6c981d78b3402
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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