反应详情

温度

78 °C

1-Hydroxybenzotriazole 1,5-dimethylpyrazole-4-carboxylate (2 g) and 5-amino-2-isobutoxybenzonitrile (1.9 g) were added to ethanol (25 ml) and the mixture was stirred at 78° C. for 3 h. After evaporation of the solvent, the residue was purified by silica gel column chromatography (mobile phase:chloroform:methanol=50:1) to give the title compound (0.8 g), melting point: 160–162° C.

1. customAfter evaporation of the solvent
2. customthe residue was purified by silica gel column chromatography (mobile phase:chloroform:methanol=50:1)