Potassium Carbonate → HCID 9800002, compound

Participants

Reaction Steps

1-(2,2,2-Trifluoroethyl)pyrazole-4-carboxylic acid (2.2 g), 5-amino-2-neopentyloxybenzonitrile (2.5 g), 1-hydroxybenzotriazole (1.8 g) and 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide (2.6 g) were added to dimethylformamide (20 ml) and the mixture was stirred at room temperature for 1.5 h. The reaction mixture was treated with aqueous potassium carbonate solution and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, after which the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the residue to allow crystallization. The crystals were recrystallized from ethyl acetate to give the title compound (1.8 g), melting point 159–160° C.

Provenance & Evidence