Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-1-propanol | HCID 12308 | — |
| Reactant | HCID 22228019 | HCID 22228019 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 22228213 | HCID 22228213 | 54.9% |
Reaction Steps
1-(4-Chlorophenyl)-N-[3-cyano-4-(piperazin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide (4.0 g), 3-bromopropanol (1.6 g) and potassium carbonate (1.6 g) were added to dimethylformamide (25 ml) and the mixture was stirred at 60° C. for 3 h. The reaction mixture was added into water, and the obtained crystals were recrystallized from hydrous dimethylformamide to give the title compound (2.5 g), melting point: 213° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07015218B1 |
|---|
| Source dataset | uspto-grants-2006_03 |
|---|
| ORD ID | ord-36a758602dc34b89aa56d9d827981805 |
|---|
| Source note | uspto-grants-2006_03 |
|---|
