化工社化工社 化学情報印刷レポート · 研究参考用
1-(3-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(3-chlorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 4423672 | — |
| 反応物 | 5-Amino-2-[4-(2-hydroxyethyl)piperazin-1-yl]benzonitrile | HCID 17609593 | — |
| 生成物 | 1-(3-chlorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide | HCID 22228097 | 12.7% |
反応手順
By the reaction and treatment in the same manner as in Example 64 using 1-(3-chlorophenyl)-5-methylpyrazole-4-carboxylic acid (2 g) and 5-amino-2-[4-(2-hydroxyethyl) piperazin-1-yl]benzonitrile (2.5 g), the title compound (0.5 g) was obtained, melting point: 176–177° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07015218B1 |
| 出典データセット | uspto-grants-2006_03 |
| ORD ID | ord-72fbb4af889a4d139d89cac581c46953 |
| 出典メモ | uspto-grants-2006_03 |