1-(3,4-Dichlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(3,4-Dichlorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl) piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide

Participants

Reaction Steps

By the reaction and treatment in the same manner as in Example 64 using 1-(3,4-dichlorophenyl)-5-methylpyrazole-4-carboxylic acid (2 g) and 5-amino-2-[4-(2-hydroxyethyl)piperazin-1-yl]benzonitrile (2.67 g), the title compound (1.2 g) was obtained, melting point: 195–197° C.

Provenance & Evidence