HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(N,N-dimethylamino)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 2777166 | — |
| Reactant | 5-amino-2-[4-(N,N-dimethylamino)piperidin-1-yl]benzonitrile | HCID 22227984 | — |
| Product | 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(N,N-dimethylamino)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide | HCID 22228204 | 30.9% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 64 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic acid (3.3 g) and 5-amino-2-[4-(N,N-dimethylamino)piperidin-1-yl]benzonitrile (2.9 g), the title compound (1.7 g) was obtained, melting point: 210–213° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-f9ed713d07f7472d863de7970dec5f35 |
| Source note | uspto-grants-2006_03 |