1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → HCID 22227919, compound

HRID 1744604Notes

Reaction equation

HRID 1744604 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=O)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][CH:29]([N:32]([CH2:36][CH2:37][OH:38])[CH2:33][CH2:34][OH:35])[CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[OH:35][CH2:34][CH2:33][N:32]([CH:29]1[CH2:30][CH2:31][N:26]([C:21]2[CH:20]=[CH:19][C:18]([NH:17][C:14]([C:11]3[CH:10]=[N:9][N:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[C:12]=3[CH3:13])=[O:16])=[CH:25][C:22]=2[C:23]#[N:24])[CH2:27][CH2:28]1)[CH2:36][CH2:37][OH:38]

Participants

3

Reactant 2

HCID 27771661-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acidHCID 22228194HCID 22228194, compound

Product 1

HCID 22227919HCID 22227919, compoundYield 9.7%

Procedure

By the reaction and treatment in the same manner as in Example 64 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic acid (1.0 g) and 5-amino-2-{4-[N,N-bis(2-hydroxyethyl)amino]piperidin-1-yl}benzonitrile (1.2 g), the title compound (0.2 g) was obtained, melting point: 230–233° C.

Sources & evidence

ORD record
ord-ebd4909c1c5f46e8b89734a03a0cf4d2
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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