HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-[4-(2-hydroxyethyl)piperazin-1-yl]benzonitrile → N-{3-Cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(3,4-difluorophenyl)-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-[4-(2-hydroxyethyl)piperazin-1-yl]benzonitrile | HCID 17609593 | — |
| Reactant | 1-(3,4-difluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 22227915 | — |
| Product | N-{3-Cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(3,4-difluorophenyl)-5-methylpyrazole-4-carboxamide | HCID 22228129 | 32.3% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 64 using 1-(3,4-difluorophenyl)-5-methylpyrazole-4-carboxylic acid (3 g) and 5-amino-2-[4-(2-hydroxyethyl)piperazin-1-yl]benzonitrile (3.7 g), the title compound (1.9 g) was obtained, melting point: 164–165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-86e156f2d9f14204bd17cb4c0dcaf948 |
| Source note | uspto-grants-2006_03 |