Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-2-[4-(2-hydroxyethyl)piperazin-1-yl]benzonitrile → 1-(3-Chloro-4-fluorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-2-[4-(2-hydroxyethyl)piperazin-1-yl]benzonitrile | HCID 17609593 | — |
| 반응물 | 1-(3-Chloro-4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 22227905 | — |
| 생성물 | 1-(3-Chloro-4-fluorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide | HCID 22227990 | — |
반응 단계
By the reaction and treatment in the same manner as in Example 64 using 1-(3-chloro-4-fluorophenyl)-5-methylpyrazole-4-carboxylic acid is (3.5 g) and 5-amino-2-[4-(2-hydroxyethyl)-piperazin-1-yl]benzonitrile (3.7 g), the title compound (1.0 g) was obtained, melting point: 191° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07015218B1 |
| 출처 데이터셋 | uspto-grants-2006_03 |
| ORD ID | ord-4db0046fa15f44d5867044f1a516cfba |
| 출처 메모 | uspto-grants-2006_03 |