1-(3,4-Dichlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(3,4-Dichlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide

HRID 1744608ノート

反応式

HRID 1744608 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([CH3:14])=[C:12]([C:15]([OH:17])=O)[CH:11]=[N:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:18][C:19]1[CH:20]=[CH:21][C:22]([N:27]2[CH2:32][CH2:31][CH:30]([N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[CH2:29][CH2:28]2)=[C:23]([CH:26]=1)[C:24]#[N:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([CH3:14])=[C:12]([C:15]([NH:18][C:19]3[CH:20]=[CH:21][C:22]([N:27]4[CH2:32][CH2:31][CH:30]([N:33]5[CH2:34][CH2:35][O:36][CH2:37][CH2:38]5)[CH2:29][CH2:28]4)=[C:23]([C:24]#[N:25])[CH:26]=3)=[O:17])[CH:11]=[N:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

3

反応物 2

HCID 167729411-(3,4-Dichlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acidHCID 219423895-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile

生成物 1

HCID 222280651-(3,4-Dichlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide収率 40.2%

実験手順

By the reaction and treatment in the same manner as in Example 64 using 1-(3,4-dichlorophenyl)-5-methylpyrazole-4-carboxylic acid (1.5 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (1.7 g), the title compound (1.2 g) was obtained, melting point: 242° C.

出典と根拠

ORDレコード
ord-464807dd26cd45f0aec865e4bc5b3c3e
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

反応ノート

読み込み中…