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5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile → 1-(3-Chloro-4-fluorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile | HCID 21942389 | — |
| 反応物 | 1-(3-Chloro-4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 22227905 | — |
| 生成物 | 1-(3-Chloro-4-fluorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide | HCID 22228087 | 42.2% |
反応手順
By the reaction and treatment in the same manner as in Example 64 using 1-(3-chloro-4-fluorophenyl)-5-methylpyrazole-4-carboxylic acid (1.5 g) and 5-amino-2-(4-morpholinopiperidin-1-yl) benzonitrile (1.9 g), the title compound (1.3 g) was obtained, melting point: 266° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07015218B1 |
| 出典データセット | uspto-grants-2006_03 |
| ORD ID | ord-6081291f7e8b48b2b30a8820a3960ba5 |
| 出典メモ | uspto-grants-2006_03 |