HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-bromophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(4-Bromophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-bromophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 2769586 | — |
| Reactant | 5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile | HCID 21942389 | — |
| Product | 1-(4-Bromophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide | HCID 22227918 | 43.4% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 64 using 1-(4-bromophenyl)-5-methylpyrazole-4-carboxylic acid (0.6 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (0.6 g), the title compound (0.5 g) was obtained, melting point: 250–252° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-cd8cabb3232e45519206c33e2b73fe71 |
| Source note | uspto-grants-2006_03 |