5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile → HCID 22227924, compound

HRID 1744620Notes

Reaction equation

HRID 1744620 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=O)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][CH:29]([N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[C:23]([C:22]1[CH:25]=[C:18]([NH:17][C:14]([C:11]2[CH:10]=[N:9][N:8]([C:5]3[CH:4]=[CH:3][C:2]([I:1])=[CH:7][CH:6]=3)[C:12]=2[CH3:13])=[O:16])[CH:19]=[CH:20][C:21]=1[N:26]1[CH2:31][CH2:30][CH:29]([N:32]2[CH2:33][CH2:34][O:35][CH2:36][CH2:37]2)[CH2:28][CH2:27]1)#[N:24]

Participants

3

Reactant 2

HCID 219423895-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrileHCID 22227884HCID 22227884, compound

Product 1

HCID 22227924HCID 22227924, compoundYield 48%

Procedure

By the reaction and treatment in the same manner as in Example 64 using 1-(4-iodophenyl)-5-methylpyrazole-4-carboxylic acid (1.2 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (1 g), the title compound (1.0 g) was obtained, melting point: 280° C.

Sources & evidence

ORD record
ord-31fe58dd46104b4ea33d4adc9c21b817
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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