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5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxylic acid → N-[3-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-1-(4-methylphenyl)-5-methylpyrazole-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxylic acid | HCID 2769583 | — |
| 反応物 | 5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile | HCID 21942389 | — |
| 生成物 | N-[3-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-1-(4-methylphenyl)-5-methylpyrazole-4-carboxamide | HCID 22227896 | 41.9% |
反応手順
By the reaction and treatment in the same manner as in Example 64 using 1-(4-methylphenyl)-5-methylpyrazole-4-carboxylic acid (1.0 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (1.4 g), the title compound (0.94 g) was obtained, melting point: 243° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07015218B1 |
| 出典データセット | uspto-grants-2006_03 |
| ORD ID | ord-1dc410a8bed24b3cbdab10a4486d8f0c |
| 出典メモ | uspto-grants-2006_03 |