Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-(4-Chlorophenyl)-N-[3-cyano-4-(4-thiomorpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride | HCID 2776128 | — |
| 반응물 | 5-Amino-2-(4-thiomorpholinopiperidin-1-yl)benzonitrile | HCID 22227879 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 1-(4-Chlorophenyl)-N-[3-cyano-4-(4-thiomorpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide | HCID 22228034 | 38% |
반응 단계
1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.67 g) and 5-amino-2-(4-thiomorpholinopiperidin-1-yl)benzonitrile (0.8 g) were added to pyridine (10 ml) and the reaction was conducted for 1 h at room temperature. To the reaction mixture was added aqueous potassium carbonate solution and the precipitated crystals were recrystallized from hydrous dimethylformamide to give the title compound (0.52 g), melting point: 256° C./decomposition.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07015218B1 |
| 출처 데이터셋 | uspto-grants-2006_03 |
| ORD ID | ord-7cfd13453c384a9da8c44f4a68b64ba1 |
| 출처 메모 | uspto-grants-2006_03 |