HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(N-(2-hydroxyethyl)-N-methylamino)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride | HCID 2776128 | — |
| Reactant | 5-Amino-2-[4-(N-2-hydroxyethyl-N-methylamino)piperidin-1-yl]benzonitrile | HCID 22228081 | — |
| Product | 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(N-(2-hydroxyethyl)-N-methylamino)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide | HCID 22227993 | 17.1% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.73 g) and 5-amino-2-[4-[N-(2-hydroxyethyl)-N-methylamino]piperidin-1-yl]benzonitrile (0.65 g), the title compound (0.2 g) was obtained, melting point: 186° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-de1f1832cbd3434796977f83b8510aad |
| Source note | uspto-grants-2006_03 |