1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → HCID 21018357, compound

HRID 1744628Notes

Reaction equation

HRID 1744628 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=O)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:27]2[CH2:32][CH2:31][CH:30]([N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[CH2:29][CH2:28]2)=[C:22]([CH:26]=1)[C:23]([NH2:25])=[O:24]>>[C:23]([C:22]1[CH:26]=[C:18]([NH:17][C:14]([C:11]2[CH:10]=[N:9][N:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[C:12]=2[CH3:13])=[O:16])[CH:19]=[CH:20][C:21]=1[N:27]1[CH2:28][CH2:29][CH:30]([N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)[CH2:31][CH2:32]1)(=[O:24])[NH2:25]

Participants

3

Reactant 2

HCID 27771661-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acidHCID 222282205-Amino-2-(4-morpholinopiperidin-1-yl)benzamide

Product 1

HCID 21018357HCID 21018357, compoundYield 21.9%

Procedure

By the reaction and treatment in the same manner as in Example 64 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic acid (2.0 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzamide (2.5 g), the title compound (0.94 g) was obtained, melting point: 270° C.

Sources & evidence

ORD record
ord-aaa57fd5d0814bd0973e24310c02d489
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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