1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → HCID 22227911, compound

HRID 1744629Notes

Reaction equation

HRID 1744629 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][CH:29]([N:32]3[CH2:37][CH2:36][N:35](C(OC(C)(C)C)=O)[CH2:34][CH2:33]3)[CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([N:26]4[CH2:31][CH2:30][CH:29]([N:32]5[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]5)[CH2:28][CH2:27]4)=[C:22]([C:23]#[N:24])[CH:25]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 22227952HCID 22227952, compound

Product 1

HCID 22227911HCID 22227911, compoundYield 41.4%

Procedure

By the reaction and treatment in the same manner as in Example 151 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.66 g) and 5-amino-2-[4-(4-tert-butoxycarbonylpiperazin-1-yl)piperidin-1-yl]benzonitrile (1.0 g), the title compound (0.54 g) was obtained, melting point: 226° C.

Sources & evidence

ORD record
ord-9101401e9b07444da27200ea9764da1b
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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