1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → HCID 22227912, compound

HRID 1744630Notes

Reaction equation

HRID 1744630 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[Br:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][C:24]=1[N:25]1[CH2:30][CH2:29][CH:28]([N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)[CH2:27][CH2:26]1)[NH2:21]>>[Br:17][C:18]1[CH:19]=[C:20]([NH:21][C:14]([C:11]2[CH:10]=[N:9][N:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[C:12]=2[CH3:13])=[O:15])[CH:22]=[CH:23][C:24]=1[N:25]1[CH2:30][CH2:29][CH:28]([N:31]2[CH2:32][CH2:33][O:34][CH2:35][CH2:36]2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 222280173-Bromo-4-(4-morpholinopiperidin-1-yl)aniline

Product 1

HCID 22227912HCID 22227912, compoundYield 54.8%

Procedure

By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (4.8 g) and 3-bromo-4-(4-morpholinopiperidin-1-yl)aniline (5 g), the title compound (4.5 g) was obtained, melting point: 205–210° C.

Sources & evidence

ORD record
ord-3d481a948b6e4b82b557fbec83f1d940
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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