4-Morpholinopiperidine → HCID 22227860, compound

HRID 1744635Notes

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][N:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)[C:15]=2[CH3:16])=[O:10])=[CH:4][C:3]=1[N+:27]([O-:29])=[O:28].[O:30]1[CH2:35][CH2:34][N:33]([CH:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH2:32][CH2:31]1>>[CH3:16][C:15]1[N:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)[N:13]=[CH:12][C:11]=1[C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([N:39]2[CH2:40][CH2:41][CH:36]([N:33]3[CH2:34][CH2:35][O:30][CH2:31][CH2:32]3)[CH2:37][CH2:38]2)=[C:3]([N+:27]([O-:29])=[O:28])[CH:4]=1)=[O:10]

Participants

Reactant 2

HCID 7957244-Morpholinopiperidine

HCID 22227916HCID 22227916, compound

Product 1

HCID 22227860HCID 22227860, compoundYield 9.1%

Procedure

The reaction and treatment in the same manner as in Example 162 using N-(4-chloro-3-nitrophenyl)-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamide (1.0 g) and 4-morpholinopiperidine (1.4 g), the title compound (0.12 g) was obtained, melting point: 225–230° C.

Sources & evidence

ORD record: ord-f3066bc1a42c446fb734227984a65ebe
Source dataset: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07015218B1

Reaction notes

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