HCID 22227909, compound → HCID 22228009, compound

HRID 1744637Notes

Reaction equation

HRID 1744637 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17](Cl)=[O:18].[CH3:20][C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=1[N:28]1[CH2:33][CH2:32][CH:31]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)[CH2:30][CH2:29]1)[NH2:24]>>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17]([NH:24][C:23]1[CH:25]=[CH:26][C:27]([N:28]2[CH2:29][CH2:30][CH:31]([N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)[CH2:32][CH2:33]2)=[C:21]([CH3:20])[CH:22]=1)=[O:18]

Participants

3

Reactant 2

HCID 22227909HCID 22227909, compoundHCID 222280865-Methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride

Product 1

HCID 22228009HCID 22228009, compoundYield 60.4%

Procedure

By the reaction and treatment the same manner as in Example 150 using 5-methyl-1-(4-trifluoromethylphenyl) pyrazole-4-carboxylic chloride (1.0 g) and 3-methyl-4-(4-morpholinopiperidin-1-yl)aniline (0.95 g), the title compound (1.1 g) was obtained, melting point: 252–255° C.

Sources & evidence

ORD record
ord-ef863a14dda3412d8638bf88e258913e
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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