HRID1744639

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22228086

未命名化合物

HCID22228177

未命名化合物

PRODUCTS

生成物

结构：CN(C)C=O.Cc1c(C(=O)Nc2ccc(N3CCC(N4CCOCC4)CC3)c(Cl)c2)cnn1-c1ccc(C(F)(F)F)cc1

HCID17822759

未命名化合物

收率 123.4%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 150 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride (0.6 g) and 3-chloro-4-(4-morpholinopiperidin-1-yl)aniline (0.61 g), the title compound (0.79 g) was obtained, melting point: 252–256° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fad9de34077542feb9e10381465aac4e
来源数据集: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07015218B1
来源说明: uspto-grants-2006_03

反应 SMILES

[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17](Cl)=[O:18].[Cl:20][C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=1[N:28]1[CH2:33][CH2:32][CH:31]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)[CH2:30][CH2:29]1)[NH2:24]>>[CH3:35][N:34]([CH3:31])[CH:39]=[O:18].[Cl:20][C:21]1[CH:22]=[C:23]([NH:24][C:17]([C:3]2[CH:4]=[N:5][N:6]([C:7]3[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=3)[C:2]=2[CH3:1])=[O:18])[CH:25]=[CH:26][C:27]=1[N:28]1[CH2:33][CH2:32][CH:31]([N:34]2[CH2:35][CH2:36][O:37][CH2:38][CH2:39]2)[CH2:30][CH2:29]1