HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → N-[4-(1-Benzylpiperidin-4-yloxy)-3-cyanophenyl]-1-(4-chlorophenyl)-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 2777166 | — |
| Reactant | 5-Amino-2-(1-benzylpiperidin-4-yloxy)benzonitrile | HCID 21942352 | — |
| Product | N-[4-(1-Benzylpiperidin-4-yloxy)-3-cyanophenyl]-1-(4-chlorophenyl)-5-methylpyrazole-4-carboxamide | HCID 22228123 | 29.2% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 64 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic acid (1.0 g) and 5-amino-2-(1-benzylpiperidin-4-yloxy)benzonitrile (1.2 g), the title compound (0.6 g) was obtained, melting point: 194° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-0c5d5d48408c4c64b41b86bebd42031f |
| Source note | uspto-grants-2006_03 |