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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1744645Generated: October 31, 2026

1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(4-Chlorophenyl)-N-{4-[4-(4-chlorophenyl)piperazin-1-yl]-3-cyanophenyl}-5-methylpyrazole-4-carboxamide

https://huagongshe.com/reaction/1744645

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acidHCID 2777166—
Reactant5-Amino-2-[4-(4-chlorophenyl)piperazin-1-yl]benzonitrileHCID 17609588—
Product1-(4-Chlorophenyl)-N-{4-[4-(4-chlorophenyl)piperazin-1-yl]-3-cyanophenyl}-5-methylpyrazole-4-carboxamideHCID 2222815249%

Reaction Steps

By the reaction and treatment in the same manner as in Example 64 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic-acid (0.5 g) and 5-amino-2-[4-(4-chlorophenyl)piperazin-1-yl]benzonitrile (0.6 g), the title compound (0.5 g) was obtained, melting point: 265° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07015218B1
Source datasetuspto-grants-2006_03
ORD IDord-ff4044368aa24585a22fabc485a88809
Source noteuspto-grants-2006_03