HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(4-Chlorophenyl)-N-{4-[4-(4-chlorophenyl)piperazin-1-yl]-3-cyanophenyl}-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 2777166 | — |
| Reactant | 5-Amino-2-[4-(4-chlorophenyl)piperazin-1-yl]benzonitrile | HCID 17609588 | — |
| Product | 1-(4-Chlorophenyl)-N-{4-[4-(4-chlorophenyl)piperazin-1-yl]-3-cyanophenyl}-5-methylpyrazole-4-carboxamide | HCID 22228152 | 49% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 64 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic-acid (0.5 g) and 5-amino-2-[4-(4-chlorophenyl)piperazin-1-yl]benzonitrile (0.6 g), the title compound (0.5 g) was obtained, melting point: 265° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-ff4044368aa24585a22fabc485a88809 |
| Source note | uspto-grants-2006_03 |