3-Methyl-1-(phenylmethyl)-1H-pyrazole-4-carboxylic acid → HCID 21018327, compound

HRID 1744646Notes

Reaction equation

HRID 1744646 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]([OH:15])=O)[C:10]([CH3:16])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][CH:29]([N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]([NH:17][C:18]2[CH:19]=[CH:20][C:21]([N:26]3[CH2:31][CH2:30][CH:29]([N:32]4[CH2:33][CH2:34][O:35][CH2:36][CH2:37]4)[CH2:28][CH2:27]3)=[C:22]([C:23]#[N:24])[CH:25]=2)=[O:15])[C:10]([CH3:16])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5428003-Methyl-1-(phenylmethyl)-1H-pyrazole-4-carboxylic acidHCID 219423895-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile

Product 1

HCID 21018327HCID 21018327, compoundYield 46.9%

Procedure

By the reaction and treatment in the same manner as in Example 64 using 1-benzyl-3-methylpyrazole-4-carboxylic acid (0.6 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (0.8 g), the title compound (0.63 g) was obtained, melting point: 193° C.

Sources & evidence

ORD record
ord-d2797d6d93a4448db05aee223e51819f
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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