5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile → HCID 21018362, compound

HRID 1744647Notes

Reaction equation

HRID 1744647 reaction equation
[CH3:1][C:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][N:4]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1.[NH2:18][C:19]1[CH:20]=[CH:21][C:22]([N:27]2[CH2:32][CH2:31][CH:30]([N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[CH2:29][CH2:28]2)=[C:23]([CH:26]=1)[C:24]#[N:25]>>[C:24]([C:23]1[CH:26]=[C:19]([NH:18][C:7]([C:6]2[C:2]([CH3:1])=[N:3][N:4]([CH2:10][CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:5]=2)=[O:9])[CH:20]=[CH:21][C:22]=1[N:27]1[CH2:32][CH2:31][CH:30]([N:33]2[CH2:34][CH2:35][O:36][CH2:37][CH2:38]2)[CH2:29][CH2:28]1)#[N:25]

Participants

3

Reactant 2

HCID 219423895-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrileHCID 222279261H-Pyrazole-4-carboxylic acid, 3-methyl-1-(2-phenylethyl)-

Product 1

HCID 21018362HCID 21018362, compoundYield 57.7%

Procedure

By the reaction and treatment in the same manner as in Example 64 using 3-methyl-1-(2-phenylethyl)pyrazole-4-carboxylic acid (0.64 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (0.8 g), the title compound (0.8 g) was obtained, melting point: 188° C.

Sources & evidence

ORD record
ord-121c002f5452483da717d76b12feaaf3
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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