HRID1744649

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2776128

1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

C11H8Cl2N2O

结构：Nc1ccc(N2CCC(N3CCOCC3)CC2)c(C(F)(F)F)c1

HCID22227917

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)Nc2ccc(N3CCC(N4CCOCC4)CC3)c(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1

HCID22227989

未命名化合物

收率 66.5%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.77 g) and 4-(4-morpholinopiperidin-1-yl)-3-trifluoromethylaniline (1 g), the title compound (1.1 g) was obtained, melting point: 193–194° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9381bcd321934b4984ef3faecdfb6714
来源数据集: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07015218B1
来源说明: uspto-grants-2006_03

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[O:17]1[CH2:22][CH2:21][N:20]([CH:23]2[CH2:28][CH2:27][N:26]([C:29]3[CH:35]=[CH:34][C:32]([NH2:33])=[CH:31][C:30]=3[C:36]([F:39])([F:38])[F:37])[CH2:25][CH2:24]2)[CH2:19][CH2:18]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:33][C:32]3[CH:34]=[CH:35][C:29]([N:26]4[CH2:25][CH2:24][CH:23]([N:20]5[CH2:21][CH2:22][O:17][CH2:18][CH2:19]5)[CH2:28][CH2:27]4)=[C:30]([C:36]([F:39])([F:38])[F:37])[CH:31]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1