1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → HCID 22227914, compound

HRID 1744650Notes

Reaction equation

HRID 1744650 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][CH:29]([N:32]([CH2:37][CH2:38][O:39][CH3:40])[CH2:33][CH2:34][O:35][CH3:36])[CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[CH3:40][O:39][CH2:38][CH2:37][N:32]([CH2:33][CH2:34][O:35][CH3:36])[CH:29]1[CH2:28][CH2:27][N:26]([C:21]2[CH:20]=[CH:19][C:18]([NH:17][C:14]([C:11]3[CH:10]=[N:9][N:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)[C:12]=3[CH3:13])=[O:15])=[CH:25][C:22]=2[C:23]#[N:24])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 22228033HCID 22228033, compound

Product 1

HCID 22227914HCID 22227914, compoundYield 34.9%

Procedure

By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.83 g) and 5-amino-2-[4-bis(2-methoxyethyl)aminopiperidin-1-yl]benzonitrile (0.9 g), the title compound (0.52 g) was obtained, melting point: 152° C.

Sources & evidence

ORD record
ord-771598b720034bc3b297f132103e2cf3
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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