HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-benzyl-5-methyl-1H-pyrazole-4-carboxylic acid → 1-Benzyl-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-benzyl-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 6493176 | — |
| Reactant | 5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile | HCID 21942389 | — |
| Product | 1-Benzyl-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide | HCID 21018328 | 22.9% |
Reaction Steps
The reaction and treatment in the same manner as in Example 64 were conducted using 1-benzyl-5-methylpyrazole-4-carboxylic acid (0.7 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (0.93 g) and the resulting product was recrystallized from a mixed solvent of ethyl acetate-diisopropyl ether to give the title compound (0.36 g), melting point: 155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-52c5f5f42a4741099048862abb88f990 |
| Source note | uspto-grants-2006_03 |