5-Methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride → HCID 21018356, compound

HRID 1744657Notes

Reaction equation

HRID 1744657 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17](Cl)=[O:18].[Cl:20][C:21]1[CH:22]=[C:23]([CH:25]=[C:26]([Cl:40])[C:27]=1[N:28]1[CH2:33][CH2:32][CH:31]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)[CH2:30][CH2:29]1)[NH2:24]>>[Cl:40][C:26]1[CH:25]=[C:23]([NH:24][C:17]([C:3]2[CH:4]=[N:5][N:6]([C:7]3[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=3)[C:2]=2[CH3:1])=[O:18])[CH:22]=[C:21]([Cl:20])[C:27]=1[N:28]1[CH2:29][CH2:30][CH:31]([N:34]2[CH2:35][CH2:36][O:37][CH2:38][CH2:39]2)[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 222280865-Methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chlorideHCID 22228178HCID 22228178, compound

Product 1

HCID 21018356HCID 21018356, compoundYield 68.4%

Procedure

By the reaction and treatment in the same manner as in Example 150 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride (0.87 g) and 3,5-dichloro-4-(4-morpholinopiperidin-1-yl)aniline (1.0 g), the title compound (1.2 g) was obtained, melting point: 252–254° C.

Sources & evidence

ORD record
ord-fe3896cbb16d4206bfe8a7d0c2889cf6
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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