HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → N-{3-Cyano-4-[4-(2-hydroxyethyl)piperidin-1-yl]phenyl}-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 4270263 | — |
| Reactant | 5-Amino-2-[4-(2-hydroxyethyl)piperidin-1-yl]benzonitrile | HCID 21942359 | — |
| Product | N-{3-Cyano-4-[4-(2-hydroxyethyl)piperidin-1-yl]phenyl}-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide | HCID 22227934 | 9.8% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 64 using 1-(4-fluorophenyl)-5-methylpyrazole-4-carboxylic acid (1 g) and 5-amino-2-[4-(2-hydroxyethyl)piperidin-1-yl]benzonitrile (1.6 g), the title compound (0.2 g) was obtained, melting point: 186° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-8a53bcef15db4e5cb946da9efe1b40fc |
| Source note | uspto-grants-2006_03 |