5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile → HCID 22227939, compound

HRID 1744662Notes

Reaction equation

HRID 1744662 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][C:10]([C:13]([OH:15])=O)=[CH:9]2)=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:18]=[CH:19][C:20]([N:25]2[CH2:30][CH2:29][N:28]([CH:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)[CH2:27][CH2:26]2)=[C:21]([CH:24]=1)[C:22]#[N:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[CH:11][C:10]([C:13]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([N:25]4[CH2:30][CH2:29][N:28]([CH:31]5[CH2:32][CH2:33][O:34][CH2:35][CH2:36]5)[CH2:27][CH2:26]4)=[C:21]([C:22]#[N:23])[CH:24]=3)=[O:15])=[CH:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 219423235-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrileHCID 22227946HCID 22227946, compound

Product 1

HCID 22227939HCID 22227939, compoundYield 36.2%

Procedure

By the reaction and treatment in the same manner as in Example 64 using 1-(4-chlorophenyl)pyrrole-3-carboxylic acid (0.5 g) and 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile (0.7 g), the title compound (0.4 g) was obtained, melting point: 224° C.

Sources & evidence

ORD record
ord-10fed440491149949fb3589ac310f3b2
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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