1-(4-bromophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(4-Bromophenyl)-N-{3-cyano-4-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide

Participants

Reaction Steps

By the reaction and treatment in the same manner as in Example 64 using 1-(4-bromophenyl)-5-methylpyrazole-4-carboxylic acid (1.0 g) and 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl) piperazin-1-yl]benzonitrile (1.0 g), the title compound (0.7 g) was obtained, melting point: 288° C.

Provenance & Evidence