HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(2-methoxyethyl)piperazin-1-yl]phenyl]-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride | HCID 2776128 | — |
| Reactant | 5-Amino-2-[4-(2-methoxyethyl)piperazin-1-yl]benzonitrile | HCID 22227937 | — |
| Product | 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(2-methoxyethyl)piperazin-1-yl]phenyl]-5-methylpyrazole-4-carboxamide | HCID 22227944 | 47.6% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.8 g) and 5-amino-2-[4-(2-methoxyethyl)piperazin-1-yl]benzonitrile (0.8 g), the title compound (0.7 g) was obtained, melting point: 207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-d030aa68f11e44a8a82a208065fa62a8 |
| Source note | uspto-grants-2006_03 |