5-Amino-2-(3-morpholinopropoxy)benzonitrile → N-[3-Cyano-4-(3-morpholinopropoxy) phenyl]-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamide

HRID 1744673Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1744673
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17](Cl)=[O:18].[NH2:20][C:21]1[CH:22]=[CH:23][C:24]([O:29][CH2:30][CH2:31][CH2:32][N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)=[C:25]([CH:28]=1)[C:26]#[N:27]>>[C:26]([C:25]1[CH:28]=[C:21]([NH:20][C:17]([C:3]2[CH:4]=[N:5][N:6]([C:7]3[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=3)[C:2]=2[CH3:1])=[O:18])[CH:22]=[CH:23][C:24]=1[O:29][CH2:30][CH2:31][CH2:32][N:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1)#[N:27]

Komponenten

3

Edukt 2

HCID 222280855-Amino-2-(3-morpholinopropoxy)benzonitrileHCID 222280865-Methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride

Produkt 1

HCID 17822715N-[3-Cyano-4-(3-morpholinopropoxy) phenyl]-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamideAusbeute 42,4 %

Versuchsvorschrift

By the reaction and treatment in the same manner as in Example 150 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride (1.0 g) synthesized according to Starting Material Synthesis Example 88 and 5-amino-2-(3-morpholinopropoxy)benzonitrile (0.9 g), the title compound (0.75 g) was obtained, melting point: 172–174° C.

Aufarbeitung

  1. customsynthesized

Quellen und Nachweise

ORD-Eintrag
ord-d2d86ca7f7394dc3ba9c214e96457609
Quelldatensatz
uspto-grants-2006_03
Patentnummer
US07015218B1

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