HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-(2-morpholinoethoxy)benzonitrile → N-[3-Cyano-4-(2-morpholinoethoxy)phenyl]-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-(2-morpholinoethoxy)benzonitrile | HCID 22228025 | — |
| Reactant | 5-Methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride | HCID 22228086 | — |
| Product | N-[3-Cyano-4-(2-morpholinoethoxy)phenyl]-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamide | HCID 22228037 | 60.9% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 150 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride (0.74 g) synthesized according to Starting Material Synthesis Example 88 and 5-amino-2-(2-morpholinoethoxy)benzonitrile (0.95 g), the title compound (0.78 g) was obtained, melting point: 191–193° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-0f272b910c0f439096bc7e85622f7555 |
| Source note | uspto-grants-2006_03 |