1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → HCID 22228223, compound

HRID 1744676Notes

Reaction equation

HRID 1744676 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:26][N:27]2[CH2:32][CH2:31][CH:30]([N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[CH2:29][CH2:28]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([CH2:26][N:27]4[CH2:28][CH2:29][CH:30]([N:33]5[CH2:38][CH2:37][O:36][CH2:35][CH2:34]5)[CH2:31][CH2:32]4)=[C:22]([C:23]#[N:24])[CH:25]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 22228103HCID 22228103, compound

Product 1

HCID 22228223HCID 22228223, compoundYield 30.9%

Procedure

By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.26 g) and 5-amino-2-((4-morpholinopiperidin-1-yl)methyl)benzonitrile (0.3 g), the title compound (0.16 g) was obtained, melting point: 167–168° C.

Sources & evidence

ORD record
ord-978811382a964d579ba8c4c6cab8aadc
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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