1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → HCID 22227888, compound

HRID 1744677Notes

Reaction equation

HRID 1744677 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([S:26][CH2:27][CH2:28][CH2:29][OH:30])=[C:22]([CH:25]=1)[C:23]#[N:24]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([S:26][CH2:27][CH2:28][CH2:29][OH:30])=[C:22]([C:23]#[N:24])[CH:25]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 22228084HCID 22228084, compound

Product 1

HCID 22227888HCID 22227888, compoundYield 25.2%

Procedure

By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (3.9 g) and 5-amino-2-(3-hydroxypropylthio)benzonitrile (2.9 g), the title compound (1.5 g) was obtained, melting point: 165° C.

Sources & evidence

ORD record
ord-43941f8706ca4591b7c200f853775208
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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