Propane sultone → HCID 87432162, compound

HRID 1744707Notes

Reaction equation

HRID 1744707 reaction equation
S(CO[CH:7]1[C:15]2[CH:14]=[CH:13][C:12]3[C:16]4[C:21]([CH:22]=[CH:23][C:11]=3[C:10]=2[NH:9][CH2:8]1)=CC=CC=4)(O)(=O)=O.C1CS(=O)(=O)[O:26][CH2:25]1>>[CH:25]([N:9]1[C:10]2[C:15](=[CH:14][CH:13]=[C:12]3[CH:16]=[CH:21][CH:22]=[CH:23][C:11]3=2)[CH2:7][CH2:8]1)=[O:26]

Participants

3

Reactant 2

HCID 14264Propane sultoneHCID 87432183HCID 87432183, compound2×

Product 1

HCID 87432162HCID 87432162, compound

Procedure

N-propylsulfonate naphthoindoline 102 (FIG. 19) was prepared by alkylation of 93 (FIG. 17) with 1,3-propane sultone with heating. Formyl-benzoindoline derivative 108 (FIG. 20) was prepared by formylation of 101 (FIG. 101) by the procedures of Example 17.

Workup

  1. temperaturewith heating

Sources & evidence

ORD record
ord-98d98ea2027d44ff89031eaf854a772d
Source dataset
uspto-grants-2006_03
Patent number
US07018431B2

Reaction notes

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