Hydrochloric Acid → HCID 21817842, compound

Participants

Reaction Steps

5.47 g (30 mmol) 1-methyl-2-oxo-4-thiono-1,2,3,4,6,7-hexahydro-5H-cyclopenta[d]pyrimidine was dissolved in 30 mL 1N NaOH. 2.18 mL (5.0 g, 35 mmol) iodomethane was added and the reaction allowed to continue for 30 minutes at room temperature during which the iodomethane gradually dissolved. The pH of the reaction mixture was adjusted to pH=7 with 2N HCl and then extracted 3 times with 50 mL chloroform. The collected chloroform fractions were washed with water, dried over MgSO4 and evaporated under reduced pressure. The residue was treated with 40 mL diethylether/hexane (1:1) and 5.16 g (88%) of the intermidiate 1-methyl-4-methylthio-2-oxo-1,2,6,7-tetrahydro-5H-cyclopenta[d]pyrimidine was obtained after filtration and drying (m.p. 139–140° C., Lit. 141–142° C.).

Provenance & Evidence