Triethylamine → HCID 21019513, compound

Participants

Reaction Conditions

Reaction Steps

A solution of triethylamine (1 ml- 7.17 mmol) in 15 ml of dry CH2Cl2 was added dropwise to a mixture of phenyl phosphorodichloridate (757.4 mg, 3.59 mmol) and L-alanine methyl ester hydrochloride (500 mg, 3.58 mmol) in 50 ml of dry CH2Cl2 at −80° C. in one hour. The mixture was then stirred vigorously at −50° C. during five hours and CH2Cl2 evaporated. 25 ml of dry ether was added and precipitate filtered off under nitrogen. Evaporation of ether gave a colourless oil which was used without further purification for the next step.

Provenance & Evidence