HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1744791Generated: October 26, 2026
Benzene, 1-ethenyl-3,5-bis(phenylmethoxy)- → 17beta-(Tert-butyldimethylsilyloxy)-7alpha-(3-(3,5-dibenzyloxyphenyl)-2-propenyl)-5alpha-androstan-3-one
https://huagongshe.com/reaction/1744791
Participants
| Role | Name | HCID | Charge |
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| Reactant | Benzene, 1-ethenyl-3,5-bis(phenylmethoxy)- | HCID 21672619 | — |
| Reactant | 7alpha-Allyl-17beta-(tert-butyldimethylsilyloxy)-5alpha-androstan-3-one | HCID 69626938 | — |
| Catalyst | Dichlororuthenium;tricyclohexyl-[phenyl-(tricyclohexyl-lambda5-phosphanyl)methyl]-lambda5-phosphane | HCID 90332616 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 17beta-(Tert-butyldimethylsilyloxy)-7alpha-(3-(3,5-dibenzyloxyphenyl)-2-propenyl)-5alpha-androstan-3-one | HCID 69627056 | — |
Reaction Steps
Under argon atmosphere, 7α-allyl-17β-(tert-butyldimethylsilyloxy)-5α-androstan-3-one (200 mg), 3,5-dibenzyloxystyrene (285 mg) and benzylidene-bis(tricyclohexylphosphine)-dichlororuthenium (37 mg) were dissolved in methylene chloride (2.5 ml) and stirred at 30° C. for 14 hours. After evaporation under reduced pressure to remove the solvent, the residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/5) to give 17β-(tert-butyldimethylsilyloxy)-7α-(3-(3,5-dibenzyloxyphenyl)-2-propenyl)-5α-androstan-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07018993B2 |
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| Source dataset | uspto-grants-2006_03 |
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| ORD ID | ord-79701daf5f684d22878e45f58f0c6585 |
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| Source note | uspto-grants-2006_03 |
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