Water → HCID 22225254, compound

Participants

Reaction Steps

To a suspension of compound E (30 g; 0.0743 mol) in 500 mL of anhydrous ethanol at 45° C. NaBH4 (15 g; 0.397 mol) was added portion-wise under vigorous stirring. After 4 h the reaction mixture was brought to room temperature and was poured into 2 L of iced water, vigorously stirred for 10′ and extracted with ethyl acetate (2×600 mL). The organic phase was washed with water until neutral pH, with brine and dried over anhydrous sodium sulphate. After evaporation the crude compound F (22 g; 82%) was used without further purification in the next step.

Provenance & Evidence