Water → HCID 11581759, compound

Participants

Reaction Steps

A mixture of compound H (19 g; 0.04423 mol) and DBU (14 mL; 0.0936) in 110 mL of N,N-diisopropylethylamine and 30 mL of THF was refluxed for 30 h. The reaction mixture was poured into 600 mL of iced water and extracted with ethyl acetate (3×500 mL). The organic phase was washed with water and brine, dried over anhydrous sodium sulphate and concentrated. The crude was purified by silica gel column chromatography (eluant: n-hexane/ethyl acetate=2/1 to 1/2) to yield compound 1 (12 g; 71%) as a yellow solid.

Provenance & Evidence