Benzocaine → HCID 22225233, compound

Participants

Reaction Steps

A solution of compound 2 (0.5 g; 1.2 mmol) and ethyl p-aminobenzoate (1 g; 6 mmol) in 10 mL of dioxane was refluxed under stirring for 14 h. The reaction mixture was concentrated, purified by silica gel column chromatography (eluant: n-hexane/ethyl acetate=1/1 to 1/2) to yield compound 3 (0.38 g; 63%).

Provenance & Evidence