HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 10217528, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl (piperidin-4-ylmethyl)carbamate | HCID 723429 | — |
| Reactant | HCID 85722021 | HCID 85722021 | — |
| Reactant | HCID 86588927 | HCID 86588927 | — |
| Product | HCID 10217528 | HCID 10217528 | — |
Reaction Steps
Using piperidin-4-ylmethyl-carbamic acid tert-butyl ester, [1-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylcarbamoyl)-piperidin-4-ylmethyl]-carbamic acid tert-butyl ester was prepared as white solid. Subsequent deprotection with trifluoroacetic acid and reaction with methanesulfonyl chloride/pyridine under standard conditions afforded the title compound as white crystals in 44% overall yield. MS: m/e=482([M−H+]−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07019001B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-3db7e0e979f9409ba4b82585426a9c1c |
| Source note | uspto-grants-2006_03 |