HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tetrahydrofuran → 8-Azaspiro(4.5)decane
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tetrahydrofuran | HCID 8028 | — |
| Edukt | Aluminium lithium hydride | HCID 21226445 | — |
| Edukt | dichloromethane MeOH Et3N | HCID 21913430 | — |
| Produkt | 8-Azaspiro(4.5)decane | HCID 437152 | 95% |
Reaktionsschritte
Was prepared from (3,3-pentamethylenglutarimide by lithium aluminium hydride reduction in tetrahydrofurane under standard conditions. Flash chromatography (silica, eluent dichloromethane/methanol/triethylamine 10:2:0.1) afforded the title compound as light yellow oil (>95% yield). MS 154(M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07019001B2 |
| Quelldatensatz | uspto-grants-2006_03 |
| ORD ID | ord-c943fc3f1bb14d4d9b585a6d5cb9aa84 |
| Quellennotiz | uspto-grants-2006_03 |