反应详情

温度

-50 °C

To a solution of 4-chloro-3-fluorobenzaldehyde (1 eq) in THF (0.3 M) at −78° C. was added 3M/Et2O MeMgBr (1.5 eq). The reaction mixture was stirred at −50° C. for 3 hrs, quenched with aqueous saturated NH4Cl and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated to give 1-(4-chloro-3-fluorophenyl)ethanol, which was used as such for the next step.

1. customquenched with aqueous saturated NH4Cl
2. extractionextracted with EtOAc
3. dry with materialThe combined organic layers were dried over Na2SO4
4. concentrationconcentrated