Water → 4'-Chloro-3'-fluoroacetophenone

HRID 1744877노트

반응식

HRID 1744877 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:10])[CH3:9])=[CH:4][C:3]=1[F:11].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[F:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 159087TriacetoxyperiodinaneHCID 219347441-(4-Chloro-3-fluorophenyl)ethan-1-ol

생성물 1

HCID 38220774'-Chloro-3'-fluoroacetophenone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of the above alcohol (1 eq) in CH2Cl2 (0.3M) at rt was added Dess-Martin periodinane (1.5 eq). The reaction mixture was stirred for 45 minutes at rt and H2O (10 eq) was added. The mixture was stirred for 30 minutes and filtered through silica gel pad eluted with 30% EtOAc/hexane and concentrated. The residue was purified by flash chromatography on silica gel eluted with 20% EtOAc/hexane to give the title compound.

후처리

  1. stirringThe mixture was stirred for 30 minutes
  2. filtrationfiltered through silica gel pad
  3. washeluted with 30% EtOAc/hexane
  4. concentrationconcentrated
  5. customThe residue was purified by flash chromatography on silica gel
  6. washeluted with 20% EtOAc/hexane

출처 및 근거

ORD 기록
ord-4e7cce125c6c432691ba44b5cc249218
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07019022B2

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